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Treatment of Patients with Papillary or Follicular Thyroid Cancer
by Sheldon Rubenfeld, M.D.
Endocrinologist, Private Practice of Thyroidology,
Endocrinology and Metabolism
Clinical Professor, Baylor College of Medicine, Houston, Texas

Reprinted with permission from Dr. Rubenfeld's book Could It Be My Thyroid?
2nd edition, 2002, copyright 1996 and 2002 by Sheldon Rubenfeld.
3rd edition available through bookstores early in 2004.

General Considerations

Some controversy exists in almost all areas of treatment of patients with differentiated thyroid cancers, but, hopefully, results from ongoing research will resolve many of these controversies. Patients with papillary or follicular thyroid cancer may receive the following treatments:

Typical Treatment of a Patient with Differentiated Thyroid Cancer*

*does not apply to a patient treated with only a lobectomy

Step 1 subtotal thyroidectomy
treatment of transient hypocalcemia
preparations for a whole body scan
Step 2
(6 weeks after surgery)
physical examination
blood tests for TSH, free T4, and thyroglobulin
thyroid ultrasound
Step 3
(1 or more days after Step 2)
whole body scan
radioactive iodine (I131) ablation
thyroid hormone replacement with levothyroxine
Step 4 (5 to 7 days after I131 ablation)
post-treatment whole body scan
Step 5 (6 to 12 weeks after starting levothyroxine)
physical examination
blood tests for TSH, free T4, and thyroglobulin
Step 6 ( 8 to 12 months after I131 ablation)
follow-up tests
additional treatment, if necessary

The selection and the sequence of different treatments and follow-up tests may be confusing. Therefore, an overview of events following the diagnosis of papillary or follicular thyroid cancer may be helpful. The table...illustrates the steps in the typical treatment of a patient with differentiated thyroid cancer. It does not apply, however, to a patient treated with a lobectomy alone or to a patient with extensive local tumor invasion who requires external-beam radiation.

Last updated: October 23, 2006